王冠,庄英萍*.生物过程工程与智能生物制造[J].中国科学院院刊,2025,40(1):107-115.

生物过程工程与智能生物制造

Bioprocess engineering and intelligent biomanufacturing

王冠
华东理工大学 生物反应器工程全国重点实验室 上海 200237;中国科学院青岛生物能源与过程研究所 青岛新能源山东省实验室 青岛 266101
WANG Guan
State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai 200237, China;Qingdao New Energy Shandong Laboratory, Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences, Qingdao 266101, China
庄英萍*
华东理工大学 生物反应器工程全国重点实验室 上海 200237;中国科学院青岛生物能源与过程研究所 青岛新能源山东省实验室 青岛 266101
ZHUANG Yingping*
State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai 200237, China;Qingdao New Energy Shandong Laboratory, Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences, Qingdao 266101, China

         生物过程;生物制造;智能感知;智能分析;智能控制

        bioprocess;biomanufacturing;intelligent sensing;intelligent analysis;intelligent control

        在合成生物学蓬勃兴起的时代背景下，生物制造作为连接生命科学与工程技术的桥梁，正逐步展现出其重塑产业格局的非凡潜力。然而，从实验室的创新成果到产业化进程的顺利推进，生物制造仍面临生产效率、成本控制及过程监控等多重挑战。智能生物制造，作为一类新质生产力，应运而生，为破解这些难题提供了创新路径。文章评述了生物过程工程与智能生物制造的最新进展，重点剖析了智能感知、智能分析与智能控制三大关键技术体系。智能感知技术，如同生物过程的“慧眼”，实现了实时、高精度的环境监测；智能分析技术，则扮演“智囊”角色，深度挖掘数据背后的规律，为决策提供依据；智能控制技术，则是“指挥官”，精准调控生物过程，确保高效稳定运行。这三者的融合应用，显著提升了生物制造的智能化水平，为突破产业化瓶颈提供了强大动力。展望未来，智能生物制造将依托持续的技术革新与跨学科合作，不断拓展应用边界，向更高效、更智能、更可持续的方向发展，为人类社会的繁荣进步贡献新的力量。

        In the era of rapid development of synthetic biology, biomanufacturing, as a bridge between life sciences and engineering technologies, is gradually demonstrating its extraordinary potential to reshape industrial landscapes. However, challenges such as production efficiency, cost control, and process monitoring still hinder the smooth transition from laboratory innovations to industrialscale implementation. Intelligent biomanufacturing has emerged as a new form of productive force, offering innovative solutions to these problems. This study reviews the latest advances in bioprocess engineering and intelligent biomanufacturing, focusing on three key technological systems: intelligent sensing, intelligent analysis, and intelligent control. Intelligent sensing technology acts as the “eyes” of biological processes, enabling real-time, high-precision environmental monitoring. Intelligent analysis, as the “brain”, uncovers underlying patterns in data, providing decision-making insights. Intelligent control, the “commander”, precisely regulates bioprocesses to ensure efficient and stable operation. The integration of these three technologies significantly enhances the intelligence of biomanufacturing, providing powerful momentum to overcome industrialization bottlenecks. Looking ahead, intelligent biomanufacturing will continue to evolve through ongoing technological innovation and interdisciplinary collaboration, expanding its applications toward greater efficiency, intelligence, and sustainability, contributing to the progress and prosperity of human society.