吴颉,周炜清,赵岚,马光辉*.微球核心技术赋能生物制药全链条创新[J].中国科学院院刊,2025,40(1):79-90.
微球核心技术赋能生物制药全链条创新
Microsphere core technology boosts innovation of biopharmaceutical industry chain
微球核心技术赋能生物制药全链条创新
Microsphere core technology boosts innovation of biopharmaceutical industry chain
作者
吴颉
中国科学院过程工程研究所 生物药制备与递送全国重点实验室 北京 100190;中国科学院大学 化学工程学院 北京 100049
WU Jie
State Key Laboratory of Biopharmaceutical Preparation and Delivery, Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100190, China;School of Chemical Engineering, University of Chinese Academy of Sciences, Beijing 100049, China
周炜清
中国科学院过程工程研究所 生物药制备与递送全国重点实验室 北京 100190;中国科学院大学 化学工程学院 北京 100049
ZHOU Weiqing
State Key Laboratory of Biopharmaceutical Preparation and Delivery, Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100190, China;School of Chemical Engineering, University of Chinese Academy of Sciences, Beijing 100049, China
赵岚
中国科学院过程工程研究所 生物药制备与递送全国重点实验室 北京 100190;中国科学院大学 化学工程学院 北京 100049
ZHAO Lan
State Key Laboratory of Biopharmaceutical Preparation and Delivery, Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100190, China;School of Chemical Engineering, University of Chinese Academy of Sciences, Beijing 100049, China
马光辉*
中国科学院过程工程研究所 生物药制备与递送全国重点实验室 北京 100190;中国科学院大学 化学工程学院 北京 100049
MA Guanghui*
State Key Laboratory of Biopharmaceutical Preparation and Delivery, Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100190, China;School of Chemical Engineering, University of Chinese Academy of Sciences, Beijing 100049, China
中国科学院过程工程研究所 生物药制备与递送全国重点实验室 北京 100190;中国科学院大学 化学工程学院 北京 100049
WU Jie
State Key Laboratory of Biopharmaceutical Preparation and Delivery, Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100190, China;School of Chemical Engineering, University of Chinese Academy of Sciences, Beijing 100049, China
周炜清
中国科学院过程工程研究所 生物药制备与递送全国重点实验室 北京 100190;中国科学院大学 化学工程学院 北京 100049
ZHOU Weiqing
State Key Laboratory of Biopharmaceutical Preparation and Delivery, Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100190, China;School of Chemical Engineering, University of Chinese Academy of Sciences, Beijing 100049, China
赵岚
中国科学院过程工程研究所 生物药制备与递送全国重点实验室 北京 100190;中国科学院大学 化学工程学院 北京 100049
ZHAO Lan
State Key Laboratory of Biopharmaceutical Preparation and Delivery, Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100190, China;School of Chemical Engineering, University of Chinese Academy of Sciences, Beijing 100049, China
马光辉*
中国科学院过程工程研究所 生物药制备与递送全国重点实验室 北京 100190;中国科学院大学 化学工程学院 北京 100049
MA Guanghui*
State Key Laboratory of Biopharmaceutical Preparation and Delivery, Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100190, China;School of Chemical Engineering, University of Chinese Academy of Sciences, Beijing 100049, China
中文关键词
生物制药;微球;细胞培养;生物分离;递送载体
英文关键词
biopharmaceutical;microspheres;cell culture;bioseparation;delivery vector
中文摘要
生命科学和生物技术的发展推动着生物制药行业的飞速进步，用于疾病预防、诊断和治疗的生物医药制品不断涌现。微球作为一种重要的功能材料，以其灵活多变的粒径、形貌、结构、功能，在生物药物的发现、制备、分离、递送等多个环节均发挥重要作用。文章结合具体应用方向，综述了微球这一关键材料近年来的重要进展及其在细胞培养、层析分离、药物递送、疫苗佐剂等领域的应用，并对其今后的发展方向提出了建议。
英文摘要
Advancements in life science and biotechnology have boosted the evolution of the biopharmaceutical industry with the continual emergence of biomedical products for disease prevention, diagnosis, and treatment. Microspheres, as crucial functional materials, play a significant role in the discovery, preparation, separation, and delivery of biological drugs due to their flexible size, morphology, structure, and function. This study reviews recent significant advancements in microspheres and their applications in cell culture, chromatographic separation, drug delivery, and as vaccine adjuvants. Additionally, it proposes future trends for the development of microspheres.
DOI10.16418/j.issn.1000-3045.20241130002
