刘佳,盛琦,刘开放,刘立明*.微生物制造饲用氨基酸助力豆粕减量替代[J].中国科学院院刊,2025,40(1):25-35.

微生物制造饲用氨基酸助力豆粕减量替代

Microbial production of feed amino acids promotes reduction and replacement of soybean meal

刘佳
江南大学 生物工程学院 工业生物技术教育部重点实验室 无锡 214122
LIU Jia
Key Laboratory of Industrial Biotechnology of Ministry of Education, School of Biotechnology, Jiangnan University, Wuxi 214122, China
盛琦
江南大学 生物工程学院 工业生物技术教育部重点实验室 无锡 214122
SHENG Qi
Key Laboratory of Industrial Biotechnology of Ministry of Education, School of Biotechnology, Jiangnan University, Wuxi 214122, China
刘开放
江南大学 生物工程学院 工业生物技术教育部重点实验室 无锡 214122
LIU Kaifang
Key Laboratory of Industrial Biotechnology of Ministry of Education, School of Biotechnology, Jiangnan University, Wuxi 214122, China
刘立明*
江南大学 生物工程学院 工业生物技术教育部重点实验室 无锡 214122
LIU Liming*
Key Laboratory of Industrial Biotechnology of Ministry of Education, School of Biotechnology, Jiangnan University, Wuxi 214122, China

         饲用氨基酸;生物制造;豆粕替代;生产菌种;合成生物学

        feed amino acid;bio-manufacturing;soybean meal reduction and substitution;strain;synthetic biology

        在豆粕减量替代及低蛋白日粮技术推广的背景下，我国已经成为全球饲用氨基酸的主要生产国。然而，我国的氨基酸工业菌种自主研发起步较晚，面临经济技术指标相对滞后、知识产权布局不够坚实的挑战。合成生物学的蓬勃发展，为氨基酸工业生产菌种的设计与优化开辟了前所未有的技术路径，为氨基酸发酵产业在全球市场竞争中带来了新的机遇。文章深入分析了饲用氨基酸在国内外的市场需求现状，系统列举了微生物制造氨基酸领域的关键技术突破，剖析了国内氨基酸行业面临的主要问题。此外，进一步展望了微生物制造氨基酸的未来发展趋势及挑战，并提出了一系列针对性的解决方案，旨在为促进氨基酸发酵行业的稳健、快速发展提供更为全面、深入的洞察与指导。

        With the promotion of soybean meal reduction and substitution as well as lower-protein diet technologies, China has become a leading global producer of feed amino acids. However, the amino acid industry faces significant challenges due to its relatively late start in independently developing industrial strains, resulting in relatively lagging key economic and technical parameters and a less robust intellectual property framework. The rapid progress of synthetic biology has provided promising avenues for the design and optimization of industrial amino acid-producing strains, offering new opportunities for the amino acid fermentation industry to enhance the global competitiveness. This study offers an in-depth analysis of the domestic and international market demand for feed amino acids, systematically reviews key technological breakthroughs in microbial amino acid production, and identifies the primary challenges confronting the domestic amino acid industry. Additionally, it further explores future development trends and challenges in microbial amino acid production, and proposes a series of targeted and comprehensive solutions to provide in-depth insights and guidance for the stable and accelerated growth of the microbial amino acid industry.