惠利健*,袁湘,吴婧琪.细胞治疗药物：进展与展望[J].中国科学院院刊,2024,39(8):1434-1446.

细胞治疗药物：进展与展望

Cell-based medicinal products: Progress and perspectives

惠利健*
中国科学院分子细胞科学卓越创新中心 200031
HUI Lijian*
Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, Shanghai 200031, China
袁湘
中国科学院分子细胞科学卓越创新中心 200031
YUAN Xiang
Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, Shanghai 200031, China
吴婧琪
中国科学院分子细胞科学卓越创新中心 200031
WU Jingqi
Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, Shanghai 200031, China

         细胞药物;细胞制备;细胞治疗

        Cell-based medicinal products;cell manufacture;cell therapy

        近年来，细胞作为一种新型药物，在疾病治疗中取得了巨大进展，尤其在多种难治性疾病治疗中获得了前所未有的成功，迅速成为全球的研究热点。文章介绍了细胞治疗的概念及其发展现状；根据细胞治疗药物的分类，系统总结了不同类型细胞作为药物在相应疾病治疗中的研究亮点；最后，对我国细胞治疗领域的整体发展趋势进行展望，特别关注了在基础研究、细胞药物化、工艺研发，以及政策层面如何进一步推动细胞药物的临床转化应用和产业化。

        Cell-based medicinal products are a breakthrough that has been proven to treat previously incurable diseases, making them a topic of global interest. This review delves into the current state and progress of cell therapy, highlighting the remarkable therapeutic effects of various types of cell-based medicinal products. We specifically explore the potential development of cell-based medicinal products in China, focusing on promoting clinical translation and commercialization. We propose necessary actions to achieve these goals, such as fostering cutting-edge basic research, innovative therapeutic approaches, scalable manufacturing processes, and policy changes.