刘翠华,任小波,汪静,逄宇,仝舟,高福.科技助力结核病防控：现状、进展与对策[J].中国科学院院刊,2022,37(1):112-122.
科技助力结核病防控：现状、进展与对策
Science and Technology Facilitates Tuberculosis Prevention and Control: Current Situation, Progress and Countermeasures
科技助力结核病防控：现状、进展与对策
Science and Technology Facilitates Tuberculosis Prevention and Control: Current Situation, Progress and Countermeasures
作者
刘翠华1*
中国科学院微生物研究所 北京 100101
LIU Cuihua1*
Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China
任小波2
中国科学院 科技促进发展局 北京 100864
REN Xiaobo2
Bureau of Science&Technology for Development, Chinese Academy of Sciences, Beijing 100864, China
汪静1
中国科学院微生物研究所 北京 100101
WANG Jing1
Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China
逄宇3
首都医科大学附属北京胸科医院 北京 101100
PANG Yu3
Beijing Chest Hospital, Capital Medical University, Beijing 101100, China
仝舟1
中国科学院微生物研究所 北京 100101
TONG Zhou1
Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China
高福1,4*
中国科学院微生物研究所 北京 100101;中国科学院微生物研究所 北京 100101
GAO George Fu1,4*
Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China;Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China
中国科学院微生物研究所 北京 100101
LIU Cuihua1*
Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China
任小波2
中国科学院 科技促进发展局 北京 100864
REN Xiaobo2
Bureau of Science&Technology for Development, Chinese Academy of Sciences, Beijing 100864, China
汪静1
中国科学院微生物研究所 北京 100101
WANG Jing1
Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China
逄宇3
首都医科大学附属北京胸科医院 北京 101100
PANG Yu3
Beijing Chest Hospital, Capital Medical University, Beijing 101100, China
仝舟1
中国科学院微生物研究所 北京 100101
TONG Zhou1
Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China
高福1,4*
中国科学院微生物研究所 北京 100101;中国科学院微生物研究所 北京 100101
GAO George Fu1,4*
Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China;Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China
中文关键词
结核分枝杆菌;结核病;结核病防控;科学技术;防控对策
英文关键词
Mycobacterium tuberculosis;tuberculosis;tuberculosis prevention and control;science and technology;prevention and control measures
中文摘要
结核分枝杆菌（Mycobacterium tuberculosis）导致的结核病（Tuberculosis，TB）这一长期困扰人类的慢性传染病至今依然是全球面临的重大公共卫生问题之一，也是单一传染性病原体致死的主要原因。目前距世界卫生组织（WHO）和联合国（UN）提出的TB控制目标尚有很大差距，如不采取紧急行动并争取尽快实现防控科技上的突破（如获得新疫苗和新药）从而快速降低TB发病率，全球TB防治目标很可能无法实现。文章总结了全球及我国TB发展态势，并分析了科技在TB防治中的贡献。基于以上分析，针对TB科技防治对策进行了思考并提出了建议，包括加强TB的基础研究、研发新型TB疫苗和药物、发展新型TB诊断技术手段、健全体系支撑并加强保障措施等，以期推进我国科技防治TB的政策布局与实践创新，最终促进WHO提出的《终止结核病战略》目标的实现。
英文摘要
Tuberculosis (TB), a chronic communicable disease caused by the pathogen Mycobacterium tuberculosis, has harassed the human being for long-term and remains to be one of the major public health problems facing the world as well as the leading cause of death from a single infectious agent. We are falling short of TB control targets set by the World Health Organization (WHO) and United Nations (UN). To achieve the ambitious targets of global TB prevention and control, there is an urgent need for immediate action as well as science and technology breakthroughs (e.g., a new vaccine and drug) to rapidly reduce TB incidence worldwide. This study summarizes the current progress on global and China's TB prevention and control, and analyzes the contribution of science and technology in TB prevention and control. Based on the above analysis, we propose the following thought and advice on strengthening TB prevention and control through science and technology:Strengthening the basic research of TB, developing new TB vaccines and drugs, developing new diagnostic techniques for TB, and perfecting the system to support and strengthen the safeguard measures. The purpose of this study is to promote the policy layout and practice innovation of scientific prevention and control of TB in China, thus speeding up the realization of goals set by the WHO End TB Strategy.
DOI10.16418/j.issn.1000-3045.20211116002
作者简介
刘翠华 中国科学院病原微生物与免疫学重点实验室研究员、博士生导师。国家杰出青年科学基金获得者。长期从事病原感染与宿主免疫等方面的研究,近年承担国家自然科学基金重点项目和国家重点基础研究发展计划项目课题等重要科研项目。在结核分枝杆菌的宿主免疫逃逸机制及宿主蛋白翻译后修饰调控机制等方面取得一系列成果,以第一和/或通讯作者在Cell、Nature Immunology、Nature Communications、PNAS、Autophagy、EMBO Reports等重要期刊发表系列研究论文。
E-mail:liucuihua@im.ac.cn
LIU Cuihua Professor and Principal Investigator in CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences (CAS). Winner of National Science Fund for Distinguished Young Scholars of National Natural Science Foundation of China (NSFC). She has been focusing on the investigation of pathogen infection and host immune defense. She has presided over a number of important projects sponsored by CAS and NSFC. Her research findings have been published in journals such as Cell, Nature Immunology, Nature Communications, PNAS, Autophagy, EMBO Reports.
E-mail:liucuihua@im.ac.cn
高福 中国科学院院士,美国国家科学院外籍院士,发展中国家科学院院士。中国疾病预防控制中心主任,国家自然科学基金委员会副主任,中国科学院病原微生物与免疫学重点实验室主任、研究员、博士生导师。长期从事病原微生物跨宿主传播、感染机制与宿主细胞免疫研究以及公共卫生政策与全球健康策略研究,做出了一系列重大突破性成果,作为通讯作者在 Nature、Science、Cell、Lancet、NEJM等国际顶级刊物上发表多篇论文。获得发展中国家科学院基础医学奖、第19届日本日经亚洲奖、俄罗斯" Gamaleya奖章"、"求是杰出科技成就集体奖"等荣誉。
E-mail:gaof@im.ac.cn
GAO George Fu Academician of Chinese Academy of Sciences (CAS), International member of National Academy of Sciences of United States of America, Fellow of the World Academy of Sciences for the advancement of science in developing countries (TWAS). Director-General of Chinese Center for Disease Control and Prevention (China CDC). Deputy Director of National Natural Science Foundation of China (NSFC). Director, Professor and Principal Investigator in CAS Key Laboratory of Pathogen Microbiology and Immunology, Institute of Microbiology, CAS. His research mainly focuses on mechanisms of interspecies transmission ("host jump") of emerging pathogens, especially interaction between the enveloped viruses and host, and molecular immune recognition, as well as public health policy and global health strategy. He has published lots of papers in journals such as Nature, Science, Cell, Lancet, NEJM. Gao is a recipient of several international and national awards, including TWAS Medical Prize, Nikkei Asian Prize (Japan), the Gamaleya Medal (Russia), HKU Centennial Distinguished Chinese Scholar, and the Qiu Shi Award for Outstanding Achievement of Scientific Research Team
E-mail:gaof@im.ac.cn
E-mail:liucuihua@im.ac.cn
LIU Cuihua Professor and Principal Investigator in CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences (CAS). Winner of National Science Fund for Distinguished Young Scholars of National Natural Science Foundation of China (NSFC). She has been focusing on the investigation of pathogen infection and host immune defense. She has presided over a number of important projects sponsored by CAS and NSFC. Her research findings have been published in journals such as Cell, Nature Immunology, Nature Communications, PNAS, Autophagy, EMBO Reports.
E-mail:liucuihua@im.ac.cn
高福 中国科学院院士,美国国家科学院外籍院士,发展中国家科学院院士。中国疾病预防控制中心主任,国家自然科学基金委员会副主任,中国科学院病原微生物与免疫学重点实验室主任、研究员、博士生导师。长期从事病原微生物跨宿主传播、感染机制与宿主细胞免疫研究以及公共卫生政策与全球健康策略研究,做出了一系列重大突破性成果,作为通讯作者在 Nature、Science、Cell、Lancet、NEJM等国际顶级刊物上发表多篇论文。获得发展中国家科学院基础医学奖、第19届日本日经亚洲奖、俄罗斯" Gamaleya奖章"、"求是杰出科技成就集体奖"等荣誉。
E-mail:gaof@im.ac.cn
GAO George Fu Academician of Chinese Academy of Sciences (CAS), International member of National Academy of Sciences of United States of America, Fellow of the World Academy of Sciences for the advancement of science in developing countries (TWAS). Director-General of Chinese Center for Disease Control and Prevention (China CDC). Deputy Director of National Natural Science Foundation of China (NSFC). Director, Professor and Principal Investigator in CAS Key Laboratory of Pathogen Microbiology and Immunology, Institute of Microbiology, CAS. His research mainly focuses on mechanisms of interspecies transmission ("host jump") of emerging pathogens, especially interaction between the enveloped viruses and host, and molecular immune recognition, as well as public health policy and global health strategy. He has published lots of papers in journals such as Nature, Science, Cell, Lancet, NEJM. Gao is a recipient of several international and national awards, including TWAS Medical Prize, Nikkei Asian Prize (Japan), the Gamaleya Medal (Russia), HKU Centennial Distinguished Chinese Scholar, and the Qiu Shi Award for Outstanding Achievement of Scientific Research Team
E-mail:gaof@im.ac.cn
