于洋,方亮星,周宇峰,孙坚,廖晓萍,刘雅红.畜牧业发展中抗菌药应用的“利”与“刃”[J].中国科学院院刊,2019,34(2):152-162.
畜牧业发展中抗菌药应用的“利”与“刃”
Benefit and Risk of Utilizing Antimicrobials in Animal Husbandry Development
畜牧业发展中抗菌药应用的“利”与“刃”
Benefit and Risk of Utilizing Antimicrobials in Animal Husbandry Development
作者
于洋
华南农业大学 兽医学院 广州 510642
YU Yang
College of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, China
方亮星
华南农业大学 兽医学院 广州 510642
FANG Liangxing
College of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, China
周宇峰
华南农业大学 兽医学院 广州 510642
ZHOU Yufeng
College of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, China
孙坚
华南农业大学 兽医学院 广州 510642
SUN Jian
College of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, China
廖晓萍
华南农业大学 兽医学院 广州 510642
LIAO Xiaoping
College of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, China
刘雅红
华南农业大学 兽医学院 广州 510642
LIU Yahong
College of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, China
华南农业大学 兽医学院 广州 510642
YU Yang
College of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, China
方亮星
华南农业大学 兽医学院 广州 510642
FANG Liangxing
College of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, China
周宇峰
华南农业大学 兽医学院 广州 510642
ZHOU Yufeng
College of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, China
孙坚
华南农业大学 兽医学院 广州 510642
SUN Jian
College of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, China
廖晓萍
华南农业大学 兽医学院 广州 510642
LIAO Xiaoping
College of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, China
刘雅红
华南农业大学 兽医学院 广州 510642
LIU Yahong
College of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, China
中文关键词
抗菌药;畜禽养殖;利弊;耐药性风险;监管
英文关键词
antimicrobials;livestock and poultry farming;benefit and risk;antimicrobial resistance;supervision and management
中文摘要
长期以来，抗菌药为畜牧业的健康发展一直起着保驾护航的重要作用，并且在将来较长时期内，抗菌药仍是集约化养殖业防治细菌病的主要手段。但随着抗菌药在养殖业的广泛使用，耐药菌的出现有可能使人类重新回到对多种感染无药可用的“前抗生素”黑暗时代，抗菌药的耐药性逐渐发展成为全球面临的挑战性问题。鉴于此，文章主要讨论抗菌药给畜牧业养殖所带来的正面影响，以及抗菌药使用所引发的全球耐药性问题，并针对我国国情提出关于抗菌药物应用和耐药性监管的策略、建议及面临的风险。
英文摘要
For decades, antimicrobials have played a key role in helping and protecting the sound development of animal husbandry. Undoubtedly, for intensive farming, antibiotics will still be one of the essential strategies for preventing and treating the bacterial infectious disease in a very long time. Nevertheless, due to the widely use of antimicrobials, the resistant bacteria and antimicrobial resistance have emerged, which become a severe challenge threatening the whole public for returning to the "pre-antibiotic era". For comprehensively understanding of this issue, here this study focuses on the pros and cons of using antibiotics in livestock, global experience in balancing the use of drugs and the control of antimicrobial resistance, and the advices and strategies are raised specifically for China.
DOI10.16418/j.issn.1000-3045.2019.02.004
作者简介
于洋 华南农业大学,博士。主要从事兽医药物代谢动力学、药物效应动力学、药动药效同步模型、以及抗生素耐药性等方向的研究。
E-mail:graceyyu@scau.edu.cn
YU Yang Ph.D., Graduated from South China Agricultural University. Her research mainly focuses on pharmacokinetics, pharmacodynamics, PK/PD modelling, and antimicrobial resistance.
E-mail:graceyyu@scau.edu.cn
刘雅红 华南农业大学校长,教授。长期从事兽医药代动力学、新兽药研发、病原微生物耐药性、与兽药残留快速检测的研究,曾获国家科技进步奖二等奖。先后主持国家杰出青年基金、教育部创新团队项目、国家自然科学基金、国家"十三五"重点研发项目等30多项科研项目。现任国务院学位委员会学科评议组成员、国家自然科学基金委员会学科评审组成员、国家农产品质量安全风险评估专家委员会委员、Animal Health Modeling and Simulation Society中国区委员。
E-mail:lyh@scau.edu.cn
LIU Yahong Professor of veterinary pharmacology and the President of South China Agricultural University (SCAU). Professor Liu has long been played a leading role in research of veterinary pharmacokinetics, development of novel veterinary antimicrobials, antimicrobial resistance, and drug residue, and achieved the Second Prize of National Science and Technology Advancement Award. She has hosted more than 30 research programs founded by the National Science Fund for Distinguished Young Scholars, the Innovation Research Team by Ministry of Education, National Key Research and Development Program of China of 13th Five-Year Plan Plan. She is a member of Academic Degrees Committee of the State Council in Veterinary Science and Animal Health Modeling and Simulation Society.
E-mail:lyh@scau.edu.cn
E-mail:graceyyu@scau.edu.cn
YU Yang Ph.D., Graduated from South China Agricultural University. Her research mainly focuses on pharmacokinetics, pharmacodynamics, PK/PD modelling, and antimicrobial resistance.
E-mail:graceyyu@scau.edu.cn
刘雅红 华南农业大学校长,教授。长期从事兽医药代动力学、新兽药研发、病原微生物耐药性、与兽药残留快速检测的研究,曾获国家科技进步奖二等奖。先后主持国家杰出青年基金、教育部创新团队项目、国家自然科学基金、国家"十三五"重点研发项目等30多项科研项目。现任国务院学位委员会学科评议组成员、国家自然科学基金委员会学科评审组成员、国家农产品质量安全风险评估专家委员会委员、Animal Health Modeling and Simulation Society中国区委员。
E-mail:lyh@scau.edu.cn
LIU Yahong Professor of veterinary pharmacology and the President of South China Agricultural University (SCAU). Professor Liu has long been played a leading role in research of veterinary pharmacokinetics, development of novel veterinary antimicrobials, antimicrobial resistance, and drug residue, and achieved the Second Prize of National Science and Technology Advancement Award. She has hosted more than 30 research programs founded by the National Science Fund for Distinguished Young Scholars, the Innovation Research Team by Ministry of Education, National Key Research and Development Program of China of 13th Five-Year Plan Plan. She is a member of Academic Degrees Committee of the State Council in Veterinary Science and Animal Health Modeling and Simulation Society.
E-mail:lyh@scau.edu.cn
