庞国芳,庞小平,任福,范春林,秦雨,陈辉.高分辨质谱-互联网-地理信息系统三元融合技术绘制中国农药残留地图[J].中国科学院院刊,2018,33(1):94-106.
高分辨质谱-互联网-地理信息系统三元融合技术绘制中国农药残留地图
Tri-element Integrated Technology of High Resolution MS, Internet, and Geographical Information System Draw A Map of Pesticide Residues in China
高分辨质谱-互联网-地理信息系统三元融合技术绘制中国农药残留地图
Tri-element Integrated Technology of High Resolution MS, Internet, and Geographical Information System Draw A Map of Pesticide Residues in China
作者
庞国芳
中国检验检疫科学研究院 北京 100176
PANG Guofang
Chinese Academy of Inspection and Quarantine, Beijing 100176, China
庞小平
武汉大学 资源与环境科学学院 武汉 430072
PANG Xiaoping
Wuhan University, Wuhan 430072, China
任福
武汉大学 资源与环境科学学院 武汉 430072
REN Fu
Wuhan University, Wuhan 430072, China
范春林
中国检验检疫科学研究院 北京 100176
FAN Chunlin
Chinese Academy of Inspection and Quarantine, Beijing 100176, China
秦雨
武汉大学 资源与环境科学学院 武汉 430072
QIN Yu
Wuhan University, Wuhan 430072, China
陈辉
中国检验检疫科学研究院 北京 100176
CHEN Hui
Chinese Academy of Inspection and Quarantine, Beijing 100176, China
中国检验检疫科学研究院 北京 100176
PANG Guofang
Chinese Academy of Inspection and Quarantine, Beijing 100176, China
庞小平
武汉大学 资源与环境科学学院 武汉 430072
PANG Xiaoping
Wuhan University, Wuhan 430072, China
任福
武汉大学 资源与环境科学学院 武汉 430072
REN Fu
Wuhan University, Wuhan 430072, China
范春林
中国检验检疫科学研究院 北京 100176
FAN Chunlin
Chinese Academy of Inspection and Quarantine, Beijing 100176, China
秦雨
武汉大学 资源与环境科学学院 武汉 430072
QIN Yu
Wuhan University, Wuhan 430072, China
陈辉
中国检验检疫科学研究院 北京 100176
CHEN Hui
Chinese Academy of Inspection and Quarantine, Beijing 100176, China
中文关键词
高分辨质谱;互联网-地理信息系统;三元融合技术;农药残留;监控;可视化
英文关键词
high resolution mass spectrometry (MS);Web-GIS;tri-element integrated technology;pesticide residue;monitor;visualization
中文摘要
如何获得海量农药残留检测结果数据并将其直观、实时地展现在地图上，是当前大数据时代背景下农药残留分析领域的重要研究内容。经过10多年的深入研究，在建立气相色谱-四极杆-飞行时间质谱（GC-Q-TOF/MS）485种和液相色谱-四极杆-飞行时间质谱（LC-Q-TOF/MS）525种农药精确质谱库的基础上，研究开发了非靶向、高通量GC-Q-TOF/MS和LC-Q-TOF/MS联用农药残留检测技术，可适用于1 200种残留农药检测。这使得农药残留检测效率得到了飞跃性的提高，为获得准确可靠的海量农药残留检测结果奠定了基础。文章将海量农药残留检测结果数据与互联网和地理信息技术相结合，研究建立了农药残留可视化系统，该系统由两部分构成：（1）在线制图系统。与Web-GIS技术相结合，并应用数据统计分析方法，创新性地以专题地图的形式，综合使用形象直观的地图、统计图表、报表等表达方式，多形式、多视角、多层次地呈现我国农药残留现状；（2）纸质地图。采用系统的思想集成表达了农药残留的空间分布、农药种类、农产品类型、残留量、毒性、超标情况等多种维度的信息。目前，农药残留可视化系统已经应用于2012—2015年采集于全国31省会/直辖市284县区638个采样点的22 278批水果和蔬菜样品的高分辨质谱农药残留筛查结果中。结果表明，基于三元融合技术构建的农药残留可视化系统，可以直观、实时展现海量农药残留数据，实现了农药残留结果的地图可视化，并将成为我国食品安全风险监控的强有力的工具。这项研究将为“十三五”国家战略发展规划中提出的实现“农药零增长”和“推进健康中国建设”提供技术和科学数据的支撑。
英文摘要
Against the background of big data age, it is important in the research of pesticide residue to find out how to get a huge mass of pesticide residue data and visualize them on the map in real time. After 10 years of in-depth study, a high-throughput high resolution mass spectrometry technique for screening of 1200 pesticide residues by gas chromatography quadrupole time of flight mass spectrometry (GC-QTOF/MS) combined with liquid chromatography quadrupole time of flight mass spectrometry (LC-Q-TOF/MS) was developed based on the accurate database and spectral library of 485 and 525 pesticides by GC-Q-TOF/MS and LC-Q-TOF/MS, respectively. This has improved the detection efficiency of pesticide residue dramatically, and also laid the foundation for obtaining massive pesticide residues detection results accurately and reliably. In this study, a pesticide residue visualization system is established by combining the massive results of pesticide residue with internet and geographic information technology (GIS). The system contains two parts:online cartography system and printed atlas. Online cartography system presents the situations of pesticide residues in China in multi-forms, multi-perspectives, and multi-levels, combining WebGIS technology with applied data statistical analysis methods, and innovatively create a web cartography system integrated using expressions such as thematic maps, statistical charts, and so on. Printed atlas illustrates the multi-dimensional information such as the spatial distribution of pesticide residues, pesticide categories, fruit and vegetable types, residues, toxicities, and excessive situation. At present, the pesticide residue visualization system has been applied to the screening results of pesticide residue of 22,278 fruit and vegetable samples collected from 638 sampling points in 284 counties within 31 provincial capitals/municipalities across the country from 2012 to 2015. It is turned out that the visualization system based on the tri-element integrated technology could show massive pesticide residue data intuitively in real time. This would be a potential and powerful tool for monitoring the risk of food safety in China. And even more important, this research will provide technical support and basic data for the implementation of the state programs of "Zero Increase of Pesticide Use" and "Boosting the Construction of Healthy China" in 13th Five-Year Plan.
DOI10.16418/j.issn.1000-3045.2018.01.011
作者简介
庞国芳 中国工程院院士,中国检验检疫科学研究院研究员,中国食品安全国家标准审评委员会副主任,中国国家食品安全风险评估专家委员会副主任,美国分析化学家协会(AOAC)资深专家,国际AOAC 2014年度Harvey W.Wiley奖获得者。30多年来始终工作在检验检疫第一线,致力于食品科学检测技术理论与实践的研究,在农药等化学污染物残留微量分析技术领域进行了开拓性的研究工作,在研究高灵敏度、高选择性、高分辨率的多残留快速检测新技术、新方法方面;在研究新型萃取、分离、富集等样品制备新技术、新方法方面多有创新。在检测技术标准化工程化方面颇有建树,研究建立了139项国家技术标准和3项国际AOAC标准。3次荣获国家科学技术进步奖二等奖,8次荣获国际AOAC科学技术奖。论著10部(2 000万字),论文100多篇(其中40篇SCI论文)。E-mail:ciqpang@163.com
PANG Guofang Academician of Chinese Academy of Engineering,the chief scientist of CAIQ,deputy director of Risk Evaluation Expert Committee of China National Food Safety,deputy director of Review Committee of China National Food Safety Standards,Fellow of Association of Official Analytical Chemists (AOAC),recipient of the 2014 Harvey W.Wiley Award.Over the past 30 years,he has been always working at the forefront of the inspection and quarantine work,devoting himself to the research on the theory and practice of food scientific analysis and conducting the pioneering research work in the field of trace element analytical techniques of pesticide and veterinary drug residues.He has made many innovations in the study of new techniques of rapid detection of multiresidues with high sensitivity,high selectivity and high resolutions as well as in the study of new techniques and new methods such as sample preparation like extraction,separation,enrichment,etc.He has focused his study on the high through-put techniques of the trace elements of over 1000 pesticides and veterinary drug residues and established 139 China National Standards and 3 AOAC Official Method.He won the Second Prize of the State Scientific and Technical Progress for 3 times and the Award of Science and Technique of AOAC for 8 times.He had 10 scientific and technical works (20 million words) and over 100 papers published,of which 40 were SCI indexed papers.E-mail:ciqpang@163.com
PANG Guofang Academician of Chinese Academy of Engineering,the chief scientist of CAIQ,deputy director of Risk Evaluation Expert Committee of China National Food Safety,deputy director of Review Committee of China National Food Safety Standards,Fellow of Association of Official Analytical Chemists (AOAC),recipient of the 2014 Harvey W.Wiley Award.Over the past 30 years,he has been always working at the forefront of the inspection and quarantine work,devoting himself to the research on the theory and practice of food scientific analysis and conducting the pioneering research work in the field of trace element analytical techniques of pesticide and veterinary drug residues.He has made many innovations in the study of new techniques of rapid detection of multiresidues with high sensitivity,high selectivity and high resolutions as well as in the study of new techniques and new methods such as sample preparation like extraction,separation,enrichment,etc.He has focused his study on the high through-put techniques of the trace elements of over 1000 pesticides and veterinary drug residues and established 139 China National Standards and 3 AOAC Official Method.He won the Second Prize of the State Scientific and Technical Progress for 3 times and the Award of Science and Technique of AOAC for 8 times.He had 10 scientific and technical works (20 million words) and over 100 papers published,of which 40 were SCI indexed papers.E-mail:ciqpang@163.com
