臧敬五.自身免疫性疾病研究的新进展——骨桥蛋白在类风湿性关节炎中的病理机制研究[J].中国科学院院刊,2005,(3):208-210.

自身免疫性疾病研究的新进展——骨桥蛋白在类风湿性关节炎中的病理机制研究

Role of Osteopontin in Amplification and Perpetuation of Rheumatoid Synovitis

臧敬五
上海生命科学研究院 上海200031
Zang Jing,Wu
Shanghai Institutes for Biological Sciences CAS, 200031 Shanghai

         骨桥蛋白;类风湿性关节炎;炎症因子

        osteopotin;rheumatoid arthritis;TNF-α

        这项研究对类风湿性关节炎的发病机理和免疫调控做了深入探索,在国际上首次阐明了骨桥蛋白在类风湿性关节炎发病中的作用,发现“骨桥蛋白”是引发类风湿性关节炎的顽凶,为治疗类风湿性关节炎找到了新的临床手段和药物靶点。本文介绍了该项成果的研究背景、意义、主要创新点及方法。

        This research article was published in the April issue of Journal of Clinical Investigation by investigators of Institute of Health Sciences, Shanghai Institutes of Biological Sciences and Shanghai Second Medical University. In this study, the authors described, for the first time, how osteopontin (OPN), a pro-inflammatory cytokine, plays an important role in the amplification and perpetuation of synovial inflammation in rheumatoid arthritis. They discovered that the over-expression of OPN in inflammatory T cells is associated with IL-10 produced in the inflamed joint and that over-expressed OPN is responsible for chemokine production of T cells. The findings have important implication in the development of novel treatment for rheumatoid arthritis.