靳刚.蛋白质芯片技术及生物医学应用[J].中国科学院院刊,2003,(5):362-364,361.

蛋白质芯片技术及生物医学应用

Protein Chip Technique and Its Bio-medical Applications

靳刚
中国科学院力学研究所 北京100080
Jin Gang
Institute of Mechanics, CAS, 100080 Beijing

         蛋白质芯片;蛋白质分析;椭偏成像;表面改性

        protein chip;protein analysis;imaging ellipsometry;surface modification

        蛋白质芯片技术是一种新型蛋白质分析技术。文章介绍了研究它的目的和意义,重点介绍它的研制过程和研究内容以及生物医学应用。

        Based on the biosensor concept with imaging ellipsometry, the proteinchip was developed as a new technique for protein analysis. The chip in micro-array was patterned with multi-bioactivity of proteins. The chip could be used for protein detection, identification and purification as well as protein interaction with only a little sample consumption and labeling free. It’s able directly to test raw physiological samples such as serum, urine, sputum, adnoid liquid, and splitted cell solution, etc. Its high spatial resolution and high throughout might be available to perform multi-analysis simultaneously with high speed and repeatability for clinic diagnosis, medicine screening and protein function analysis.