冰冻圈微生物演变与生物安全
Microbial Evolution of Cryosphere and Biosecurity Concerns
Microbial Evolution of Cryosphere and Biosecurity Concerns
作者
徐静阳1(中国科学院微生物研究所 北京 100101)
张强弓2(中国科学院青藏高原研究所 北京 100101)
施一1*(中国科学院微生物研究所 北京 100101)
张强弓2(中国科学院青藏高原研究所 北京 100101)
施一1*(中国科学院微生物研究所 北京 100101)
中文关键词
冰冻圈;微生物;气候变化;致病菌;病毒;生物安全
英文关键词
cryosphere;microbes;climate change;pathogens;virus;biosecurity
中文摘要
冰冻圈独特而极端的生态环境蕴藏着丰富的微生物资源，保存了关于古微生物多样性和进化历史的珍贵记录。气候变化和人类活动正在对全球生态系统造成显著影响，冰冻圈加速消融缩减使原本冻存其中的微生物被“解封”，一些微生物适应新的环境条件从而复苏存活，随之构成对生态环境和人类健康的未知威胁。为此，亟待联合多学科研究力量，调查研究冰冻圈微生物资源，解析其中病原微生物的致病和传播机制，充分评估休眠微生物复苏释放带来的生物安全风险。
英文摘要
The unique and extreme ecological environment of cryosphere acts as a gigantic reservoir of microorganisms, which preserves precious records of the diversity and evolutionary history of ancient microbes. Climate change and human activities have made significant impacts on the ecological system. Global warming causes melting of the cryosphere that remained frozen for thousands of years and releases microorganisms, some of them are recovered to life and constitute a potential threat to the ecological environment and human health. It is urgent to combine multidisciplinary research forces to investigate the microbial ecology of cryosphere, analyze the microbe pathogenesis and transmission mechanisms, as well as evaluate the biosecurity risks caused by the reboot of dormant microorganisms.
DOI10.16418/j.issn.1000-3045.20210407005
作者简介
徐静阳 中国科学院微生物研究所高级工程师。曾先后在清华大学、日本东京工业大学、美国麻省理工学院等机构学习和进行工业微生物技术相关研究,在PNAS、Nature Metabolism等学术期刊发表论文10余篇。
E-mail:xujingyang@im.ac.cn
XU Jingyang Senior Engineer at Institute of Microbiology,Chinese Academy of Sciences (CAS).Dr.Xu has studied and conducted research in Tsinghua Univerity,Tokyo Institute of Technology,and Massechusetts Institute of Technology in the field of industrial microbial technologies.She has published more than 10 SCI indexed papers in PNAS,Nature Metabolism,etc.
E-mail:xujingyang@im.ac.cn
施一中国科学院微生物研究所研究员,中国科学院病原微生物与免疫学重点实验室副主任。中国青年科技工作者协会生物与医药科学专业委员会秘书长,中国科学院青年创新促进会第五届理事会理事长。长期从事病原感染调控的分子机制、免疫细胞受体与配体相互作用与识别机制研究,以及药物研发。对流感病毒、埃博拉病毒、寨卡病毒、沙粒病毒、冠状病毒等的感染过程进行了深入研究,取得一系列重要进展。曾担任国家传染病科技重大专项项目首席科学家,主持国家自然科学基金优秀青年基金、面上项目,以及中国科学院战略性先导科技专项项目、中国科学院青年创新促进会优秀会员项目等。发表SCI论文100余篇,其中以第一或通讯作者在Cell、Nature、Science等期刊发表20余篇。
E-mail:shiyi@im.ac.cn
SHI Yi Principal Investigator and Professor at Institute of Microbiology,Chinese Academy of Sciences (CAS).Deputy Director for CAS Key Laboratory of Pathogenic Microbiology and Immunology (CASPMI).He is also the Secretary General of the Biological and Medical Sciences Committee of the Chinese Association of Young Scientists and Technologists,Director General of Youth Innovation Promotion Association of CAS.Dr.Shi mainly focuses on the molecular mechanism of pathogen infection and regulation by the host,and the interaction between receptors and ligands during immune response.He has been supported by the National Science and Technology Major Project (as Chief Scientist),the Excellent Young Scientists Fund of National Natural Science Foundation of China,the Strategic Priority Research Program of CAS,and Youth Innovation Promotion Association of CAS (excellent member).He has made remarkable contribution on the infection mechanism of several important human pathogens including Influenza virus,Ebola virus,ZIKV,arenavirus,and coronaviruses.More than 100 SCI indexed papers have been published in international academic journals,including more than 20 of them,as first or corresponding authors (including co-first or corresponding),published in Cell,Nature,Science,etc.
E-mail:shiyi@im.ac.cn
E-mail:xujingyang@im.ac.cn
XU Jingyang Senior Engineer at Institute of Microbiology,Chinese Academy of Sciences (CAS).Dr.Xu has studied and conducted research in Tsinghua Univerity,Tokyo Institute of Technology,and Massechusetts Institute of Technology in the field of industrial microbial technologies.She has published more than 10 SCI indexed papers in PNAS,Nature Metabolism,etc.
E-mail:xujingyang@im.ac.cn
施一中国科学院微生物研究所研究员,中国科学院病原微生物与免疫学重点实验室副主任。中国青年科技工作者协会生物与医药科学专业委员会秘书长,中国科学院青年创新促进会第五届理事会理事长。长期从事病原感染调控的分子机制、免疫细胞受体与配体相互作用与识别机制研究,以及药物研发。对流感病毒、埃博拉病毒、寨卡病毒、沙粒病毒、冠状病毒等的感染过程进行了深入研究,取得一系列重要进展。曾担任国家传染病科技重大专项项目首席科学家,主持国家自然科学基金优秀青年基金、面上项目,以及中国科学院战略性先导科技专项项目、中国科学院青年创新促进会优秀会员项目等。发表SCI论文100余篇,其中以第一或通讯作者在Cell、Nature、Science等期刊发表20余篇。
E-mail:shiyi@im.ac.cn
SHI Yi Principal Investigator and Professor at Institute of Microbiology,Chinese Academy of Sciences (CAS).Deputy Director for CAS Key Laboratory of Pathogenic Microbiology and Immunology (CASPMI).He is also the Secretary General of the Biological and Medical Sciences Committee of the Chinese Association of Young Scientists and Technologists,Director General of Youth Innovation Promotion Association of CAS.Dr.Shi mainly focuses on the molecular mechanism of pathogen infection and regulation by the host,and the interaction between receptors and ligands during immune response.He has been supported by the National Science and Technology Major Project (as Chief Scientist),the Excellent Young Scientists Fund of National Natural Science Foundation of China,the Strategic Priority Research Program of CAS,and Youth Innovation Promotion Association of CAS (excellent member).He has made remarkable contribution on the infection mechanism of several important human pathogens including Influenza virus,Ebola virus,ZIKV,arenavirus,and coronaviruses.More than 100 SCI indexed papers have been published in international academic journals,including more than 20 of them,as first or corresponding authors (including co-first or corresponding),published in Cell,Nature,Science,etc.
E-mail:shiyi@im.ac.cn
