合成生物学工业应用的现状和展望
Current Situations and Perspectives of Industrial Applications of Synthetic Biology
Current Situations and Perspectives of Industrial Applications of Synthetic Biology
作者
曾艳(中国科学院科技促进发展局 北京 100864)
赵心刚(中国科学院科技促进发展局 北京 100864)
周桔(中国科学院科技促进发展局 北京 100864)
赵心刚(中国科学院科技促进发展局 北京 100864)
周桔(中国科学院科技促进发展局 北京 100864)
中文关键词
合成生物学;化学品;细胞工厂;多酶分子机器
英文关键词
synthetic biology;chemicals;cell factories;multi-enzyme molecular machines
中文摘要
通过合成生物学技术可以实现化学品的生物合成，从而为摆脱石油资源依赖提供了可能。合成生物学技术的发展极大地提高了微生物细胞工厂生产化学品的能力，创造的新菌种、新工艺可以有效替代传统工艺，显著降低污染，大幅减少能耗，提升传统发酵行业的技术水平。文章对利用合成生物学技术构建细胞工厂以及构建多酶分子机器来生产化学品的关键因素和典型案例进行了综述，并对合成生物学技术工业应用的未来进行了展望。
英文摘要
Biosynthesis of chemicals through synthetic biology can partially relieve the dependence on petroleum resources. With the development of synthetic biology technology, the capabilities of constructing microbial cell factories for production of chemicals have been greatly improved. Development of new engineered strains and new bioprocess can replace the traditional manufacturing process, decrease the energy cost and pollution, and improve the producing capabilities of traditional fermentation industry. In this review, key factors and representative cases for constructing microbial cell factories and multi-enzyme molecular machines to produce chemicals were summarized. The future of industrial applications of synthetic biology were also discussed.
DOI10.16418/j.issn.1000-3045.2018.11.009
作者简介
曾艳 中国科学院科技促进发展局生物技术处副研究员,工业生物催化专业博士。主要从事生物技术领域科研管理及成果转化等工作。
E-mail:zengyan@cashq.ac.cn
ZENG Yan Associate Professor of Bureau of Science and Technology for Development,Chinese Academy of Sciences (CAS),Ph.D.of biocatalysis.She is mainly responsible for biotechnology projects management,techtransfer,etc.
E-mail:zengyan@cashq.ac.cn
周桔 中国科学院科技促进发展局生物技术处处长,生物化学专业博士。主要从事生物技术领域科研管理及成果转化等工作。
E-mail:zhouju@cashq.ac.cn
ZHOU Ju Director of Division of Biotechnology,Bureau of Science and Technology for Development,Chinese Academy of Sciences (CAS),Ph.D.of biochemistry.He is mainly responsible for biotechnology projects management,tech-transfer,etc.
E-mail:zhouju@cashq.ac.cn
E-mail:zengyan@cashq.ac.cn
ZENG Yan Associate Professor of Bureau of Science and Technology for Development,Chinese Academy of Sciences (CAS),Ph.D.of biocatalysis.She is mainly responsible for biotechnology projects management,techtransfer,etc.
E-mail:zengyan@cashq.ac.cn
周桔 中国科学院科技促进发展局生物技术处处长,生物化学专业博士。主要从事生物技术领域科研管理及成果转化等工作。
E-mail:zhouju@cashq.ac.cn
ZHOU Ju Director of Division of Biotechnology,Bureau of Science and Technology for Development,Chinese Academy of Sciences (CAS),Ph.D.of biochemistry.He is mainly responsible for biotechnology projects management,tech-transfer,etc.
E-mail:zhouju@cashq.ac.cn
